Invitrogen

Phospho-DKK1 (Ser140) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-DKK1 (Ser140) Polyclonal Antibody

Product Details

PA5-105051

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human DKK1(Accession O94907), corresponding to amino acid residues around phosphorylated Ser140.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816524

Product Specific Information

Antibody detects endogenous levels of DKK1 only when phosphorylated at Ser140.

Target Information

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dickkopf 1 homolog; dickkopf related protein-1; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; Dickkopf1; dkk-1; hDkk-1; hDkk1; SK

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Gene Aliases: DKK-1; DKK1; mdkk-1; SK; UNQ492/PRO1008

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UniProt ID: (Human) O94907, (Mouse) O54908

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Entrez Gene ID: (Human) 22943, (Mouse) 13380

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Function(s)
signal transducer activity protein binding growth factor activity co-receptor binding receptor antagonist activity low-density lipoprotein particle receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis involved in differentiation endoderm formation mesoderm formation hair follicle development regulation of receptor internalization negative regulation of Wnt signaling pathway embryonic limb morphogenesis negative regulation of BMP signaling pathway forebrain development negative regulation of protein binding response to retinoic acid negative regulation of peptidyl-serine phosphorylation negative regulation of mesodermal cell fate specification regulation of endodermal cell fate specification negative regulation of skeletal muscle tissue development negative regulation of synapse assembly regulation of synaptic transmission, glutamatergic face morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation motor learning positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis extracellular negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment regulation of dopaminergic neuron differentiation midbrain morphogenesis negative regulation of Wnt-Frizzled-LRP5/6 complex assembly negative regulation of cardiac muscle cell differentiation multicellular organism development endoderm development Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of protein complex assembly head morphogenesis negative regulation of receptor activity
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