Bioss

Phospho-ABCA1 (Ser2054) Polyclonal Antibody

View all (18) ABCA1 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-ABCA1 (Ser2054) Polyclonal Antibody

Product Details

BS-12956R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human ABCA1 around the phosphorylation site of Ser2054.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABC 1; ABC 1 antibody; ABC Transporter 1; ABC-1; ABC1 antibody; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; ATP-binding cassette, sub-family A (ABC1), member 1; CERP antibody; Cholesterol efflux regulatory protein; membrane-bound; Phospholipid-transporting ATPase ABCA1

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Gene Aliases: ABC-1; ABC1; ABCA1; CERP; HDLDT1; TGD

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UniProt ID: (Human) O95477, (Mouse) P41233

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Entrez Gene ID: (Human) 19, (Mouse) 11303, (Rat) 313210

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Function(s)
receptor binding protein binding ATP binding phospholipid binding phospholipid transporter activity anion transmembrane transporter activity cholesterol binding cholesterol transporter activity syntaxin binding small GTPase binding apolipoprotein binding apolipoprotein A-I binding apolipoprotein A-I receptor activity ATPase activity, coupled to transmembrane movement of substances ATPase binding nucleotide binding transporter activity ATPase activity
Process(es)
peptide secretion protein lipidation transport phagocytosis, engulfment lysosome organization G-protein coupled receptor signaling pathway cholesterol metabolic process positive regulation of cholesterol efflux phospholipid transport endosomal transport cholesterol transport positive regulation of cAMP biosynthetic process intracellular cholesterol transport regulation of Cdc42 protein signal transduction cholesterol efflux phospholipid efflux high-density lipoprotein particle assembly apolipoprotein A-I-mediated signaling pathway lipoprotein metabolic process lipoprotein biosynthetic process cholesterol homeostasis reverse cholesterol transport phospholipid translocation interleukin-1 beta secretion transmembrane transport phospholipid homeostasis response to high density lipoprotein particle platelet dense granule organization cellular response to lipopolysaccharide cellular response to retinoic acid anion transmembrane transport response to nutrient ion transmembrane transport response to laminar fluid shear stress response to drug response to low-density lipoprotein particle cellular response to cholesterol negative regulation of macrophage derived foam cell differentiation negative regulation of cholesterol storage
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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