Invitrogen

Pan-cadherin Monoclonal Antibody (R.976.9)

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View all (16) Pan-cadherin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-15036

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

R.976.9

Immunogen

Synthetic peptide corresponding to a conserved region of human N-, R-, E- and P-Cadherin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10984067

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ARC-1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; Cadherin-N; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Epithelial cadherin; N-cadherin; N-cadherin 1; Neural cadherin; Neural-cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; Uvomorulin

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Gene Aliases: AA960649; AI385538; Arc-1; AW120700; CAD4; Cadp; CD324; CD325; CDH1; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; E-cad; ECAD; HJMD; L-CAM; LCAM; N-cadherin; NCAD; P-cadherin; PCAD; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO

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UniProt ID: (Human) P12830, (Human) P19022, (Human) P22223, (Human) Q9BZ05, (Mouse) P09803, (Rat) Q9R0T4, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038

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Entrez Gene ID: (Human) 999, (Human) 1000, (Human) 1001, (Human) 1002, (Mouse) 12550, (Rat) 83502, (Mouse) 12558, (Rat) 83501, (Rat) 116777, (Mouse) 12560, (Mouse) 12561, (Rat) 114588

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Function(s)
glycoprotein binding calcium ion binding protein binding beta-catenin binding ankyrin binding GTPase activating protein binding gamma-catenin binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion protein kinase binding protein phosphatase binding protein complex binding alpha-catenin binding nitric-oxide synthase binding molecular_function protein domain specific binding metal ion binding enzyme binding
Process(es)
cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules synapse assembly regulation of signal transduction glial cell differentiation single organismal cell-cell adhesion calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration regulation of myelination regulation of protein localization regulation of Rho protein signal transduction positive regulation of MAPK cascade cell-cell adhesion mediated by cadherin blood vessel morphogenesis regulation of axonogenesis striated muscle cell differentiation protein heterooligomerization negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering retina homeostasis positive regulation of gene expression positive regulation of keratinocyte proliferation hair cycle process keratinization positive regulation of monophenol monooxygenase activity negative regulation of transforming growth factor beta2 production wound healing response to drug positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of melanin biosynthetic process negative regulation of catagen canonical Wnt signaling pathway regulation of hair cycle by canonical Wnt signaling pathway positive regulation of melanosome transport axon guidance positive regulation of axon extension in utero embryonic development trophectodermal cell differentiation epithelial cell morphogenesis sensory perception of sound protein metabolic process negative regulation of cell-cell adhesion regulation of water loss via skin adherens junction organization positive regulation of transcription factor import into nucleus regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of transcription, DNA-templated regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation protein homooligomerization intestinal epithelial cell development salivary gland cavitation regulation of branching involved in salivary gland morphogenesis bicellular tight junction assembly cellular response to amino acid stimulus cellular response to lithium ion cellular response to indole-3-methanol protein localization to plasma membrane establishment of protein localization to plasma membrane cochlea development regulation of protein localization to cell surface regulation of neuron migration response to toxic substance response to organic substance pituitary gland development neuron projection development visual perception cerebral cortex development brain morphogenesis homeostasis of number of cells positive regulation of muscle cell differentiation radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation extracellular matrix disassembly extracellular matrix organization
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