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Invitrogen
PYGL Polyclonal Antibody
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Product Details
PA5-52054
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Shipping conditions
RRID
Product Specific Information
Immunogen sequence: VVAATLQDII RRFKASKFGS TRGAGTVFDA FPDQVAIQLN DTHPALAIPE LMRIFVDIEK LPWSKAWELT QKTFAYTNHT VLPEALERWP VDLVEKLLPR HLEIIYEINQ KHLDRIVALF PKDVDRLRRM SLI
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Target Information
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: glycogen liver; Glycogen phosphorylase, liver form; GPLL
Gene Aliases: GSD6; PYGL
UniProt ID: (Human) P06737
Entrez Gene ID: (Human) 5836
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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