Invitrogen

PTPN22 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
PTPN22 Polyclonal Antibody

Product Details

PA5-118870

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PTPN22(Accession Q9Y2R2), corresponding to amino acid residues K770-I807.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2903370

Product Specific Information

Antibody detects endogenous levels of total PTPN22.

Target Information

The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; PEP; PEST domain-enriched tyrosine phosphatase; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 22

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Gene Aliases: 70zpep; LYP; LYP1; LYP2; PEP; PTPN22; PTPN8

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UniProt ID: (Human) Q9Y2R2, (Mouse) P29352

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Entrez Gene ID: (Human) 26191, (Rat) 295338, (Mouse) 19260

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Function(s)
protein tyrosine phosphatase activity protein binding phosphatase activity SH3 domain binding kinase binding ubiquitin protein ligase binding molecular_function phosphoprotein phosphatase activity hydrolase activity
Process(es)
protein dephosphorylation biological_process T cell differentiation regulation of natural killer cell proliferation peptidyl-tyrosine dephosphorylation phosphoanandamide dephosphorylation T cell receptor signaling pathway regulation of T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation immune system process autophagy dephosphorylation negative regulation of autophagy positive regulation of gene expression negative regulation of gene expression lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide negative regulation of tumor necrosis factor production positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway negative regulation of JUN kinase activity regulation of innate immune response regulation of B cell receptor signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to muramyl dipeptide negative regulation of interleukin-6 secretion regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination positive regulation of interferon-gamma secretion negative regulation of p38MAPK cascade negative regulation of interleukin-8 secretion
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