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Abnova
PTPN22 Polyclonal Antibody, MaxPab™
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Product Details
H00026191-B01P
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY SVLIIVMACM EYEMGKKKCE RYWAEPGEMQ LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS ETRTIYQFHY KNWPDHDVPS SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI DYTWMLLKDG SQAKHCIPEK NHTLQADSYS PNLPKSTTKA AKMMNQQRTK MEIKESSSFD FRTSEISAKE ELVLHPAKSS TSFDFLELNY SFDKNADTTM KWQTKAFPIV GEPLQKHQSL DLGSLLFEGC SNSKPVNAAG RYFNSKVPIT RTKSTPFELI QQRETKEVDS KENFSYLESQ PHDSCFVEMQ AQKVMHVSSA ELNYSLPYDS KHQIRNASNV KHHDSSALGV YSYIPLVENP YFSSWPPSGT SSKMSLDLPE KQDGTVFPSS LLPTSSTSLF SYYNSHDSLS LNSPTNISSL LNQESAVLAT APRIDDEIPP PLPVRTPESF IVVEEAGEFS PNVPKSLSSA VKVKIGTSLE WGGTSEPKKF DDSVILRPSK SVKLRSPKSE LHQDRSSPPP PLPERTLESF FLADEDCMQA QSIETYSTSY PDTMENSTSS KQTLKTPGKS FTRSKSLKIL RNMKKSICNS CPPNKPAESV QSNNSSSFLN FGFANRFSKP KGPRNPPPTW NI
Target Information
The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 22
Gene Aliases: LYP; LYP1; LYP2; PEP; PTPN22; PTPN8
UniProt ID: (Human) Q9Y2R2
Entrez Gene ID: (Human) 26191
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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