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Invitrogen
PSME4 Polyclonal Antibody
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FIGURE: 1 / 4
PSME4 Antibody (PA5-89458) in IHC (P)
Product Details
PA5-89458
Species Reactivity
Host/Isotype
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Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: LYPHQVPLVL QVLKQTARSS SWHARYTVLT YLQTMVFYNL FIFLNNEDAV KDIRWLVISL LEDEQLEVRE MAATTLSGLL QCNFLTMDSP MQIHFEQLCK TKLPKKRKRD PGSVGDTIPS AELVKRHAGV LGLGACVLSS PYDVPTWMPQ LLMNLSAHLN DPQPIEMTVK KTLSNFRRTH HDNWQEHKQQ FTDDQLLVLT DLLVSPCYYA; Positive Samples: MCF-7, U-87MG, 293T, HeLa, Mouse thymus, Mouse brain, Mouse heart, Mouse kidney, Rat liver; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle, cytosol
Target Information
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Blm10; proteasome (prosome, macropain) activator subunit 4; proteasome activator 200 kDa; Proteasome activator complex subunit 4; Proteasome activator PA200; Protein BLM10 homolog; Protein TEMO
Gene Aliases: AA409398; AU041366; BLM10; KIAA0077; mKIAA0077; PA200; PSME4; TEMO
UniProt ID: (Human) Q14997, (Mouse) Q5SSW2
Entrez Gene ID: (Human) 23198, (Mouse) 103554, (Rat) 498433
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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