Invitrogen

PSD-95 Recombinant Rabbit Monoclonal Antibody (23H23L19)

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View all (40) PSD-95 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

700902

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:1,000
-

ELISA (ELISA)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

23H23L19

Immunogen

proprietary

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532348

Product Specific Information

700902 has been successfully used in immunofluorescence analysis of PSD95 in human motor neurons derived from iPSCs.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: discs large homolog 4; Disks large homolog 4; FLJ97752; FLJ98574; post synaptic density; post-synaptic density protein 95; Postsynaptic density protein 95; PSD-95; SAP-90; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15

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Gene Aliases: DLG4; Dlgh4; PSD95; SAP-90; SAP90

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UniProt ID: (Human) P78352, (Rat) P31016

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Entrez Gene ID: (Human) 1742, (Rat) 29495

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Function(s)
guanylate kinase activity Ras guanyl-nucleotide exchange factor activity protein binding protein C-terminus binding ligand-gated ion channel activity kinase binding protein phosphatase binding PDZ domain binding beta-1 adrenergic receptor binding D1 dopamine receptor binding P2Y1 nucleotide receptor binding protein complex binding acetylcholine receptor binding ionotropic glutamate receptor binding neuroligin family protein binding scaffold protein binding receptor binding protein kinase binding glutamate receptor binding
Process(es)
negative regulation of receptor internalization protein complex assembly positive regulation of cytosolic calcium ion concentration synaptic vesicle maturation social behavior protein localization to synapse locomotory exploration behavior neuronal ion channel clustering establishment of protein localization establishment or maintenance of epithelial cell apical/basal polarity nucleotide phosphorylation regulation of long-term neuronal synaptic plasticity positive regulation of synaptic transmission neuromuscular process controlling balance dendritic spine morphogenesis vocalization behavior AMPA glutamate receptor clustering receptor localization to synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential regulation of grooming behavior MAPK cascade signal transduction chemical synaptic transmission nervous system development learning ion transmembrane transport positive regulation of GTPase activity GMP metabolic process GDP metabolic process
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