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  • Primary Antibodies ›
  • PPM1B Antibodies

OriGene

PPM1B Monoclonal Antibody (OTI3E10), TrueMAB™

View all (31) PPM1B antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite PPM1B Monoclonal Antibody (OTI3E10), TrueMAB™

  • Antibody Testing Data (4)
PPM1B Antibody in Western Blot (WB)
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PPM1B Antibody in Western Blot (WB)
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FIGURE: 1 / 4

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PPM1B Antibody (TA502863) in WB

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPM1B (RC212918, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PPM1B. Positive lysates LY419156 (100 µg) and LC419156 (20 µg) can be purchased separately from OriGene. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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PPM1B Antibody in Western Blot (WB)
PPM1B Antibody in Flow Cytometry (Flow)
PPM1B Antibody in Flow Cytometry (Flow)
PPM1B Antibody in Flow Cytometry (Flow)

Product Details

TA502863

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Flow Cytometry (Flow)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI3E10

Immunogen

Full length human recombinant protein of human PPM1B produced in HEK293T cell.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.42 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PP2C-beta; Protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase, Mg2+/Mn2+ dependent, 1B; Ser/Thr protein phosphatase type 2C beta 2 isoform

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Gene Aliases: PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; PPM1B

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UniProt ID: (Human) O75688

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Entrez Gene ID: (Human) 5495

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Function(s)
magnesium ion binding protein serine/threonine phosphatase activity protein binding manganese ion binding
Process(es)
protein dephosphorylation N-terminal protein myristoylation negative regulation of interferon-beta production peptidyl-threonine dephosphorylation negative regulation of NF-kappaB import into nucleus negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of defense response to virus
It has to be done as per old AB suggested Products section.
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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