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Proteintech
PPAPDC3 Polyclonal Antibody
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Product Details
20635-1-AP
Species Reactivity
Published species
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: MPASQSRAR ARDRNNVLNR AEFLSLNQPP KGGPEPRSSG RKASGPSAQP PPAGDGARER RQSQQL (1-65 aa encoded by BC006362)
Target Information
PPAPDC3, also known as nuclear envelope transmembrane protein 39 (NET39), was initially discovered in an in silico screen for secreted or membrane proteins. It is a member of the PAP2 superfamily of phosphatases and haloperoxidases. PPAPDC3 has recently been shown to act as a negative regulator of myoblast differentiation by diminishing the activity of the mammalian target of rapamycin TOR. PPAPDC3 is highly expressed in cardiac and skeletal muscle and becomes strongly upregulated during cultured myoblast differentiation tissues. Overexpression of PPAPDC3 in myoblasts repressed myogenesis while knockdown by RNA interference promoted differentiation indicating its part in the regulatory mechanism for myogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Inactive phospholipid phosphatase 7; Nuclear envelope transmembrane protein 39; nuclear envelope transmembrane protein NET39; phosphatidic acid phosphatase type 2 domain containing 3; Phosphatidic acid phosphatase type 2 domain-containing protein 3; probable lipid phosphate phosphatase PPAPDC3; RP11-643E14.1
Gene Aliases: C9orf67; D830019K17Rik; NET39; PLPP7; PPAPDC3; RGD1305821
UniProt ID: (Human) Q8NBV4, (Rat) Q5FVJ3, (Mouse) Q91WB2
Entrez Gene ID: (Human) 84814, (Rat) 296635, (Mouse) 227721
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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