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Invitrogen
POLB Recombinant Rabbit Monoclonal Antibody (HL1525)
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FIGURE: 1 / 2
POLB Antibody (MA5-47080) in ICC/IF
Product Details
MA5-47080
Species Reactivity
Host/Isotype
Expression System
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Clone
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Conjugate
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Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 5'-deoxyribose-phosphate lyase; 5'-dRP lyase; AP lyase; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; MGC125976; POL B; polymerase (DNA directed), beta; polymerase (DNA) beta; polymerase B
Gene Aliases: POLB; wu:fa97a05; zgc:109924
UniProt ID: (Human) P06746
Entrez Gene ID: (Human) 5423, (Zebrafish) 554204
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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