Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
PNPT1 Monoclonal Antibody (3F2A1)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
PNPT1 Antibody (68309-1-IG) in WB
Product Details
68309-1-IG
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: YEFPPYATNE IGKVTGLNRR ELGHGALAEK ALYPVIPRDF PFTIRVTSEV LESNGSSSMA SACGGSLALM DSGVPISSAV AGVAIGLVTK TDPEKGEIED YRLLTDILGI EDYNGDMDFK IAGTNKGITA LQADIKLPGI PIKIVMEAIQ QASVAKKEIL QIMNKTISKP RASRKENGPV VETVQVPLSK RAKFVGPGGY NLKKLQAETG VTISQVDEET FSVFAPTPSA MHEARDFITE ICKDDQEQQL EFGAVYTATI TEIRDTGVMV KLYPNMTAVL LHNTQLDQRK IKHPTALGLE VGQEIQVKYF GRDPADGRMR LSRKVLQSPA TTVVRTLNDR SSIVMGEPIS QSSSNSQ
Target Information
PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondirla) is a RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. It plays a role as a cytoplasmic RNA import factor, in mitochondrial morphogenesis and respiration, regulation of expression of the electron transport chain, regulation of the stability of specific mature miRNAs in melanoma cells, and RNA cell surveilance. Mutations of the gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and deafness, autosomal recessive, 70 (DFNB70).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 3'-5' RNA exonuclease OLD35; DKFZp762K1914; old 35; PNPase 1; PNPase old-35; Polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein; Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Gene Aliases: 1200003F12Rik; COXPD13; DFNB70; old-35; OLD35; PNPASE; PNPT1; Pnptl1
UniProt ID: (Human) Q8TCS8, (Mouse) Q8K1R3
Entrez Gene ID: (Human) 87178, (Rat) 360992, (Mouse) 71701
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support