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  • PMSCL1 Antibodies

Invitrogen

PMSCL1 Polyclonal Antibody

View all (9) PMSCL1 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite PMSCL1 Polyclonal Antibody

  • Antibody Testing Data (2)
PMSCL1 Antibody in Immunocytochemistry (ICC/IF)
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PMSCL1 Antibody in Immunocytochemistry (ICC/IF)
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PMSCL1 Antibody (PA5-59749) in ICC/IF

Immunofluorecent analysis of PMSCL1 in human cell line A-431 using PMSCL1 Polyclonal Antibody (Product # PA5-59749). Staining shows localization to nucleoli. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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PMSCL1 Antibody in Immunocytochemistry (ICC/IF)
PMSCL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
PMSCL1 Polyclonal Antibody

Product Details

PA5-59749

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PMSCL1. Recombinant protein control fragment (Product #RP-96639).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2645700

Product Specific Information

Immunogen sequence: CVVAGEKVWQ IRVDLHLLNH DGNIIDAASI AAIVALCHFR RPDVSVQGDE VTLYTPEERD PVPLSIHHMP ICVSFA

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Autoantigen PM/Scl 1; Exosome complex component RRP45; exosome complex exonuclease RRP45; Exosome component 9; P75 polymyositis-scleroderma overlap syndrome associated autoantigen; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-75; PMSCL autoantigen, 75kD; Polymyositis/scleroderma autoantigen 1; polymyositis/scleroderma autoantigen 1, 75kDa; Polymyositis/scleroderma autoantigen 75 kDa

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Gene Aliases: EXOSC9; p5; p6; PM/Scl-75; PMSCL1; RRP45; Rrp45p

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UniProt ID: (Human) Q06265

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Entrez Gene ID: (Human) 5393

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Function(s)
3'-5'-exoribonuclease activity RNA binding exoribonuclease activity protein binding AU-rich element binding poly(A) RNA binding
Process(es)
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process rRNA processing immune response positive regulation of cell growth nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing regulation of mRNA stability exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process
It has to be done as per old AB suggested Products section.
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