Proteintech

PI3 Kinase p110 Alpha Monoclonal Antibody (1F6A7), CoraLite® 594

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Datasheet
Protocols
Questions & Answers
PI3 Kinase p110 Alpha Monoclonal Antibody (1F6A7), CoraLite® 594

Product Details

CL594-67071

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.4 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1F6A7

Immunogen

Recombinant protein
View immunogen

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLITIKHELF KEARKYPLHQ LLQDESSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK VIEPVGNREE KILNREIGFA IGMPVCEFDM VKDPEVQDFR RNILNVCKEA VDLRDLNSPH SRAMYVYPPN VESSPELPKH IYNKLDKGQI IVVIWVIVSP NNDKQKYTLK INHDCVPEQV IAEAIRKKTR SMLLSSEQLK LCVLEYQGKY ILKVCGCDEY FLEKYPLSQY KYIRSCIMLG RMPNLMLMAK ESLYSQLPMD CFTMPSYSRR ISTATPYMNG ETSTKSLWVI NSALRIKILC ATYVNVNIRD IDKIY

Target Information

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; pi3kca; PIK3R1; pk3ca; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA

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Gene Aliases: CLOVE; CWS5; MCAP; MCM; MCMTC; p110-alpha; PI3K; PI3K-alpha; PIK3CA

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UniProt ID: (Human) P42336

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Entrez Gene ID: (Human) 5290

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Function(s)
protein serine/threonine kinase activity protein binding ATP binding kinase activity 1-phosphatidylinositol-3-kinase activity protein kinase activator activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Process(es)
angiogenesis liver development vasculature development glucose metabolic process protein phosphorylation phosphatidylinositol biosynthetic process epidermal growth factor receptor signaling pathway regulation of gene expression regulation of phosphatidylinositol 3-kinase signaling platelet activation T cell costimulation activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process insulin receptor signaling pathway via phosphatidylinositol 3-kinase Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway regulation of multicellular organism growth regulation of cellular respiration protein kinase B signaling negative regulation of neuron apoptotic process endothelial cell migration hypomethylation of CpG island phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway phosphatidylinositol-mediated signaling T cell receptor signaling pathway leukocyte migration cardiac muscle contraction adipose tissue development cellular response to glucose stimulus energy homeostasis mitophagy in response to mitochondrial depolarization negative regulation of fibroblast apoptotic process regulation of genetic imprinting negative regulation of anoikis
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