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  • P2X7 Antibodies

Alomone Labs, LTD

P2X7 Receptor Polyclonal Antibody

View all (28) P2X7 antibodies

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Datasheet
Protocols
Questions & Answers

Cite P2X7 Receptor Polyclonal Antibody

  • Antibody Testing Data (2)
P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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P2X7 Receptor Antibody (APR-004-200UL) in IHC (P)

Expression of P2X7 Receptorin rat pancreas - Immunohistochemical staining of rat paraffin-embedded endocrine and exocrine pancreas sections using Anti-P2X7 Receptor Antibody (#APR-004), (1:50), followed by goat Anti-rabbit-AlexaFluor-555-secondary Antibody (1:500), (red). Staining is highly specific for endocrine cells of theIsle of Langerhans.Hoechst 33342 is used as the counterstain (blue). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
P2X7 Receptor Antibody in Western Blot (WB)
P2X7 Receptor Polyclonal Antibody

Product Details

APR-004-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)KIRKEFPKTQGQYSGFKYPY, corresponding to amino acid residues 576-595 of rat P2X7 receptor, Intracellular, C-terminus
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.6 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A

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Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R

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UniProt ID: (Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0

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Entrez Gene ID: (Human) 5027, (Rat) 29665, (Mouse) 18439

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Function(s)
lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity magnesium ion binding receptor activity copper ion binding zinc ion binding channel activity protein serine/threonine kinase activator activity scaffold protein binding ion channel activity
Process(es)
activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization cell surface receptor signaling pathway response to mechanical stimulus response to bacterium response to organic substance response to zinc ion gene expression positive regulation of calcium ion transport into cytosol programmed cell death positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion response to organic cyclic compound organic cation transport synaptic vesicle exocytosis protein processing neuronal action potential sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis positive regulation of apoptotic process positive regulation of catalytic activity NAD transport negative regulation of MAPK cascade positive regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation positive regulation of ossification negative regulation of bone resorption positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to organic cyclic compound reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway cation transmembrane transport transport ion transport positive regulation of gene expression phospholipid scrambling positive regulation of ion transmembrane transport negative regulation of cell volume positive regulation of glycolytic process cellular response to dsRNA positive regulation of bleb assembly blood coagulation regulation of killing of cells of other organism
It has to be done as per old AB suggested Products section.
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