Invitrogen

P2X7 Polyclonal Antibody

1 Published Figure
2 References
View all (28) P2X7 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
P2X7 Polyclonal Antibody

Product Details

PA5-25581

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
- -

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 563-592 amino acids of human P2RX7
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2543081

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A

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Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R

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UniProt ID: (Human) Q99572, (Mouse) Q9Z1M0

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Entrez Gene ID: (Human) 5027, (Mouse) 18439

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Function(s)
lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity receptor activity ion channel activity channel activity
Process(es)
activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane transport ion transport cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization response to mechanical stimulus response to bacterium response to organic substance response to zinc ion gene expression positive regulation of calcium ion transport into cytosol positive regulation of gene expression programmed cell death positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion response to organic cyclic compound synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis positive regulation of apoptotic process positive regulation of catalytic activity NAD transport negative regulation of MAPK cascade positive regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation positive regulation of ossification negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization response to calcium ion response to electrical stimulus membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA cellular response to organic cyclic compound reactive oxygen species metabolic process extrinsic apoptotic signaling pathway cation transmembrane transport positive regulation of bleb assembly regulation of sodium ion transport cell surface receptor signaling pathway blood coagulation positive regulation of cytolysis positive regulation of cytoskeleton organization regulation of killing of cells of other organism apoptotic signaling pathway
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