Osenses

P2RY1 Polyclonal Antibody

2 References
View all (24) P2Y1 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

OSP00121W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:2,000
-

Immunohistochemistry (IHC)

1:300-1:2,000
-

Miscellaneous PubMed (MISC)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Guinea pig, Human

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from the extracellular domain of human P2Y1 (P2RY1) conjugated to an immunogenic carrier protein was used as the antigen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: P2RY1.

Target Information

P2Y1 is a Purinergic Receptor that causes a change in platelet shape and potentially leads to platelet aggregation by binding ADP, which results in the mobilization of intracellular calcium ions via activation of phospholipase C. This receptor also mediates the release of the relaxing factor nitric oxide and may be involved in the modulation of neuronal signal transmission. P2Y1 has been reported to be expressed in tissues throughout the body, particularly brain. ESTs have been isolated from human embryo, lung, and placenta libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ADP receptor; ATP receptor; P2 purinoceptor subtype Y1; P2Y purinoceptor 1; p2y-1-r; P2Y1; P2Y1 purinoceptor; p2y1r; platelet ADP receptor; Purinergic receptor; purinergic receptor P2Y, G-protein coupled, 1; Purinoceptor p2y1; Purinoceptor p2yr1

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Gene Aliases: P2RY1; P2Y1

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UniProt ID: (Human) P47900, (Guinea pig) P59902

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Entrez Gene ID: (Human) 5028, (Guinea pig) 100135592

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Function(s)
receptor activity protein binding ATP binding A1 adenosine receptor binding ADP binding G-protein coupled purinergic nucleotide receptor activity ATP-activated adenosine receptor activity ADP-activated adenosine receptor activity protein heterodimerization activity scaffold protein binding
Process(es)
positive regulation of protein phosphorylation adenosine receptor signaling pathway cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration aging glial cell migration response to mechanical stimulus regulation of receptor activity negative regulation of norepinephrine secretion sensory perception of pain signal transduction involved in regulation of gene expression platelet activation positive regulation of inositol trisphosphate biosynthetic process G-protein coupled purinergic nucleotide receptor signaling pathway regulation of vasodilation eating behavior positive regulation of ion transport positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion negative regulation of binding positive regulation of penile erection positive regulation of ERK1 and ERK2 cascade response to growth factor cellular response to organic cyclic compound protein localization to plasma membrane relaxation of muscle
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