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Proteintech
P-cadherin Monoclonal Antibody (1G10F7)
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Product Details
66295-1-IG
Species Reactivity
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Conjugate
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Product Specific Information
Immunogen sequence: SEPCRAVFR EAEVTLEAGG AEQEPGQALG KVFMGCPGQE PALFSTDNDD FTVRNGETVQ ERRSLKERNP LKIFPSKRIL RRHKRDWVVA PISVPENGKG PFPQRLNQLK SNKDRDTKIF YSITGPGADS PPEGVFAVEK ETGWLLLNKP LDREEIAKYE LFGHAVSENG ASVEDPMNIS IIVTDQNDHK PKFTQDTFRG SVLEGVLPGT SVMQMTATDE DDAIYTYNGV VAYSIHSQEP KDPHDLMFTI HRSTGTISVI SSGLDREKVP EYTLTIQATD MDGDGSTTTA VAVVEILDAN DNAPMFDPQK YEAHVPENAV GHEVQRL (24-349 aa encoded by BC041846)
Target Information
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CADH3; cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; P-cadherin; Placental cadherin; Placental-cadherin
Gene Aliases: CDH3; CDHP; HJMD; PCAD
UniProt ID: (Human) P22223
Entrez Gene ID: (Human) 1001
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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