Invitrogen

OGG1 Recombinant Rabbit Monoclonal Antibody (8V2Q9)

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Datasheet
Protocols
Questions & Answers
OGG1 Recombinant Rabbit Monoclonal Antibody (8V2Q9)

Product Details

MA5-35616

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8V2Q9

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 246-345 of human OGG1 (O15527)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849516

Product Specific Information

Immunogen sequence: VGTKVADCIC LMALDKPQAV PVDVHMWHIA QRDYSWHPTT SQAKGPSPQT NKELGNFFRS LWGPYAGWAQ AVLFSADLRQ SRHAQEPPAK RRKGSKGPEG

Target Information

8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; N-glycosylase/DNA lyase; OGG1 type 1f

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Gene Aliases: HMMH; HOGG1; MMH; MUTM; OGG1; OGH1

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UniProt ID: (Human) O15527, (Mouse) O08760, (Rat) O70249

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Entrez Gene ID: (Human) 4968, (Mouse) 18294, (Rat) 81528

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Function(s)
damaged DNA binding endonuclease activity protein binding microtubule binding oxidized purine nucleobase lesion DNA N-glycosylase activity oxidized purine DNA binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity purine-specific mismatch base pair DNA N-glycosylase activity oxidized base lesion DNA N-glycosylase activity DNA binding catalytic activity DNA-(apurinic or apyrimidinic site) lyase activity uracil DNA N-glycosylase activity hydrolase activity hydrolase activity, acting on glycosyl bonds lyase activity single-strand selective uracil DNA N-glycosylase activity DNA N-glycosylase activity DNA-3-methylbase glycosylase activity nicotinamide riboside hydrolase activity nicotinic acid riboside hydrolase activity deoxyribonucleoside 5'-monophosphate N-glycosidase activity
Process(es)
acute inflammatory response base-excision repair regulation of transcription, DNA-templated cellular response to DNA damage stimulus response to oxidative stress aging response to radiation response to light stimulus response to estradiol regulation of protein import into nucleus, translocation nucleotide-excision repair, DNA incision response to drug negative regulation of apoptotic process depurination depyrimidination response to ethanol response to folic acid cellular response to cadmium ion negative regulation of double-strand break repair via single-strand annealing DNA repair nucleotide-excision repair metabolic process nucleic acid phosphodiester bond hydrolysis DNA catabolic process, endonucleolytic
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