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Nicotinic Acetylcholine Receptor alpha 7 Polyclonal Antibody, FITC

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Nicotinic Acetylcholine Receptor alpha 7 Polyclonal Antibody, FITC

Product Details

NACR-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetylcholine receptor; acetylcholine receptor alpha 7 neural; alpha7 nicotinic receptor; alpha7-nAChR; bungarotoxin alpha; C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor; cholinergic receptor, nicotinic, alpha polypeptide 7; CHRFAM7A; CHRNA7-DR1; D-10; nAChR alpha7; nAChR7; Neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; Nicotinic acetylcholine receptor subunit alpha-7; nicotinic receptor alpha 7 subunit

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Gene Aliases: Acra7; alpha7; BTX; Chrna7; nAchR; nAChRa7; NARAD

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UniProt ID: (Rat) Q53YK2, (Mouse) P49582

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Entrez Gene ID: (Rat) 25302, (Mouse) 11441

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Function(s)
beta-amyloid binding acetylcholine-activated cation-selective channel activity protein binding drug binding adenylate cyclase binding acetylcholine receptor activity toxic substance binding chloride channel regulator activity protein kinase binding acetylcholine-gated cation channel activity acetylcholine binding protein homodimerization activity ATPase binding scaffold protein binding ion channel activity extracellular ligand-gated ion channel activity
Process(es)
activation of MAPK activity response to hypoxia positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure ion transport calcium ion transport cellular calcium ion homeostasis endocytosis signal transduction synaptic transmission, cholinergic memory positive regulation of cell proliferation associative learning regulation of norepinephrine secretion neuronal action potential sperm motility response to food regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production ion transmembrane transport response to nicotine behavioral response to nicotine T cell activation B cell activation regulation of membrane potential dopamine biosynthetic process ovulation cycle response to ethanol positive regulation of angiogenesis behavioral response to ethanol regulation of inflammatory response negative regulation of inflammatory response cognition generation of ovulation cycle rhythm cation transmembrane transport transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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