NeoBiotechnologies

Neurofilament (H+L) (Neuronal Marker) Monoclonal Antibody (RT-97, NR-4)

View all (10) NEFL/NEFH antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Neurofilament (H+L) (Neuronal Marker) Monoclonal Antibody (RT-97, NR-4)

Product Details

MSM2-1201-P0

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

0.25-0.5 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-
Product Specifications

Species Reactivity

Chicken, Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

RT-97, NR-4

Immunogen

Triton-X 100 insoluble proteins of rat brain (RT-97). Neurofilaments from porcine spinal cord (NR-4)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 200 kDa neurofilament protein; 68 kDa neurofilament protein; light molecular weight neurofilament protein; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament light polypeptide; neurofilament protein L; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet H protein; Neurofilament triplet L protein; neurofilament, heavy polypeptide 200kDa; neurofilament, light polypeptide 68kDa; NF-H; NF-L; protein phosphatase 1, regulatory subunit 110

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Gene Aliases: AI847934; CMT1F; CMT2CC; CMT2E; KIAA0845; mKIAA0845; NEFH; NEFL; NF-H; NF-L; NF200; NF68; NFH; NFL; PPP1R110

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UniProt ID: (Human) P12036, (Human) P07196, (Mouse) P19246, (Mouse) P08551, (Rat) P19527

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Entrez Gene ID: (Human) 4744, (Human) 4747, (Pig) 100521224, (Rat) 24587, (Mouse) 380684, (Mouse) 18039, (Rat) 83613

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Function(s)
structural molecule activity structural constituent of cytoskeleton microtubule binding toxic substance binding kinesin binding protein kinase binding protein binding, bridging dynein binding protein heterodimerization activity Ras guanyl-nucleotide exchange factor activity protein binding protein C-terminus binding protein domain specific binding identical protein binding phospholipase binding nutrient reservoir activity
Process(es)
MAPK cascade microtubule cytoskeleton organization anterograde axonal transport retrograde axonal transport response to toxic substance peripheral nervous system axon regeneration axonal transport of mitochondrion spinal cord development hippocampus development cerebral cortex development regulation of axon diameter neurofilament bundle assembly locomotion response to peptide hormone negative regulation of neuron apoptotic process positive regulation of GTPase activity intermediate filament polymerization or depolymerization intermediate filament organization neuron projection morphogenesis positive regulation of axonogenesis neuromuscular process controlling balance protein polymerization response to corticosterone response to sodium arsenite response to acrylamide ovarian follicle atresia axonogenesis cell projection assembly axon regeneration cellular response to oxidative stress response to cocaine peripheral nervous system neuron axonogenesis axon development cellular response to estradiol stimulus regulation of organelle transport along microtubule intermediate filament bundle assembly neurofilament cytoskeleton organization brain development embryo development neuron projection development intermediate filament cytoskeleton organization response to organic substance response to organonitrogen compound
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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