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  • TrkC Antibodies

NeoBiotechnologies

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Monoclonal Antibody (NTRK3/7140)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Cite NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Monoclonal Antibody (NTRK3/7140)

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Monoclonal Antibody (NTRK3/7140)

Product Details

4916-MSM2-P1ABX

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

NTRK3/7140

Immunogen

Recombinant fragment (around aa100-300) of human NTRK3 protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

Positive Control:Human nervous tissue.

Cellular Location: Membrane.

Target Information

NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C

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Gene Aliases: gp145(trkC); GP145-TrkC; NTRK3; TRKC

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UniProt ID: (Human) Q16288

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Entrez Gene ID: (Human) 4916

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Function(s)
p53 binding GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding neurotrophin binding
Process(es)
activation of MAPK activity neuron migration negative regulation of protein phosphorylation positive regulation of protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway heart development circadian rhythm positive regulation of cell proliferation positive regulation of gene expression peptidyl-tyrosine phosphorylation modulation by virus of host transcription positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation neurotrophin signaling pathway mechanoreceptor differentiation positive regulation of apoptotic process response to ethanol protein autophosphorylation ephrin receptor signaling pathway neuron fate specification response to axon injury positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation positive regulation of positive chemotaxis response to corticosterone positive regulation of synapse assembly negative regulation of cell death lens fiber cell differentiation cellular response to retinoic acid cochlea development activation of GTPase activity positive regulation of actin cytoskeleton reorganization
It has to be done as per old AB suggested Products section.
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