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NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) Monoclonal Antibody (NTRK2/4673)

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Datasheet
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Datasheet
Protocols
Questions & Answers
NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) Monoclonal Antibody (NTRK2/4673)

Product Details

4915-MSM4-P1

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2, kappa

Class

Monoclonal

Type

Antibody

Clone

NTRK2/4673

Immunogen

Recombinant fragment (around aa250-450) of human NTRK2 protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control:Human brain tissue.

Cellular Location: Cell surface.

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AI848316; BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; NTRK 2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB tyrosine kinase; Tropomyosin-related kinase B; tyrosine kinase receptor B

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Gene Aliases: GP145-TrkB; NTRK2; trk-B; TRKB

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UniProt ID: (Human) Q16620

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Entrez Gene ID: (Human) 4915

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Function(s)
ATP binding receptor tyrosine kinase binding protein homodimerization activity neurotrophin binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity
Process(es)
vasculogenesis neuron migration positive regulation of protein phosphorylation inflammatory response neuromuscular junction development aging learning long-term memory circadian rhythm feeding behavior positive regulation of cell proliferation response to light stimulus positive regulation of gene expression positive regulation of neuron projection development response to auditory stimulus glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway mechanoreceptor differentiation regulation of GTPase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process retinal rod cell development protein autophosphorylation regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis
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