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Proteintech
NR2F6 Monoclonal Antibody (2H2B8)
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Product Details
60117-2-IG
Species Reactivity
Published species
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Type
Clone
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Conjugate
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Product Specific Information
Immunogen sequence: MAMVTGGWG GPGGDTNGVD KAGGYPRAAE DDSASPPGAA SDAEPGDEER PGLQVDCVVC GDKSSGKHYG VFTCEGCKSF FKRSIRRNLS YTCRSNRDCQ IDQHHRNQCQ YCRLKKCFRV GMRKEAVQRG RIPHSLPGAV AASSGSPPGS ALAAVASGGD LFPGQPVSEL IAQLLRAEPY PAAAGRFGAG GGAAGAVLGI DNVCELAARL LFSTVEWARH APFFPELPVA DQVALLRLSW SELFVLNAAQ AALPLHTAPL LAAAGLHAAP MAAERAVAFM DQVRAFQEQV DKLGRLQVDS AEYGCLKAIA LFTPDACGLS DPAHVESLQE KAQVALTEYV RAQYPSQPQR FGRLLLRLPA LRAVPASLIS QLFFMRLVGK TPIETLIRDM LLSGSTFNWP YGSGQ (1-404 aa encoded by BC002669)
Target Information
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EAR-2; Erba related 2; ERBA-related gene-2; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; nuclear receptor V-erbA-related; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2
Gene Aliases: EAR-2; EAR2; ERBAL2; NR2F6
UniProt ID: (Human) P10588
Entrez Gene ID: (Human) 2063
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