Abnova

NR2E1 Monoclonal Antibody (2D10)

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Datasheet
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Datasheet
Protocols
Questions & Answers
NR2E1 Monoclonal Antibody (2D10)

Product Details

H00007101-M02

Applications
Tested Dilution
Publications

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2D10

Immunogen

NR2E1 (NP_003260, 249 a.a. approximately 342 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.32 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: NGDNTDSQKL NKIISEIQAL QEVVARFRQL RLDATEFACL KCIVTFKAVP THSGSELRSF RNAAAIAALQ DEAQLTLNSY IHTRYPTQPC RFGK

Target Information

Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HTll; Nuclear receptor subfamily 2 group E member 1; nuclear receptor subfamily 2, group E, member 1; Nuclear receptor TLX; Protein tailless homolog; tailes-related receptor; Tll

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Gene Aliases: NR2E1; TLL; TLX; XTLL

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UniProt ID: (Human) Q9Y466

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Entrez Gene ID: (Human) 7101

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Function(s)
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding steroid hormone receptor activity zinc ion binding histone deacetylase binding sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter behavioral fear response aggressive behavior transcription initiation from RNA polymerase II promoter nervous system development visual perception dentate gyrus development amygdala development olfactory bulb development layer formation in cerebral cortex forebrain generation of neurons cerebral cortex neuron differentiation anterior commissure morphogenesis extracellular matrix organization somatic stem cell population maintenance social behavior negative regulation of apoptotic process steroid hormone mediated signaling pathway cell fate commitment negative regulation of neuron differentiation positive regulation of angiogenesis positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter negative regulation of astrocyte differentiation regulation of dendrite morphogenesis retina development in camera-type eye regulation of timing of neuron differentiation long-term synaptic potentiation regulation of cell migration involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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