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Proteintech
NOTCH2/NOTCH2NL Monoclonal Antibody (2D5E1)
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Product Details
68212-1-IG
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: PAHALQCRDG YEPCVNEGMC VTYHNGTGYC KCPEGFLGEY CQHRDPCEKN RCQNGGTCVA QAMLGKATCR CASGFTGEDC QYSTSHPCFV SRPCLNGGTC HMLSRDTYEC TCQVGFTGKE CQWTDACLSH PCANGSTCTT VANQFSCKCL TGFTGQKCET DVNECDIPGH CQHGGICLNL PGSYQCQCLQ GFTGQYCDSL YVPCAPSPCV NGGTCRQTGD FTFECNCLPE TVRRGTELWE RDREVWNGKE HDEN
Target Information
NOTCH2 and NOTCH2NL are members of the Notch receptor family, with NOTCH2 being a transmembrane receptor located on the cell surface. It plays a critical role in cell-to-cell communication during development and tissue homeostasis, affecting cell fate determination, differentiation, proliferation, and apoptosis. NOTCH2 is composed of an extracellular domain with epidermal growth factor-like repeats, a transmembrane domain, and an intracellular domain. On the other hand, NOTCH2NL proteins are also transmembrane proteins that modulate NOTCH2 signaling. They can act as competitive inhibitors or enhancers of NOTCH2 signaling, depending on the specific paralog and cellular context. They are involved in neuronal development and have been linked to human brain evolution, particularly in neocortex expansion. Both NOTCH2 and NOTCH2NL are important players in cellular processes and have structural similarities, but NOTCH2NL proteins have distinct arrangements of domains compared to NOTCH2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Neurogenic locus notch homolog protein 2; Notch 2; Notch homolog 2; Notch homolog 2 N-terminal like protein; Notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A
Gene Aliases: AGS2; HJCYS; hN2; N2N; NOTCH2; NOTCH2NL; NOTCH2NLA
UniProt ID: (Human) Q04721, (Human) Q7Z3S9
Entrez Gene ID: (Human) 4853, (Human) 388677
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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