Invitrogen

NOTCH2 Chimeric Recombinant Rabbit Monoclonal Antibody (B9)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-47822

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

10 µg/mL
-

ELISA (ELISA)

Assay-dependent
-

Inhibition Assays (IA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

B9

Immunogen

NRR of mouse Notch 2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074269

Product Specific Information

Specificity: An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2 but not NRR1.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Motch B; Neurogenic locus notch homolog protein 2; Notch 2; Notch gene homolog 2; Notch homolog 2

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Gene Aliases: AGS2; AI853703; HJCYS; hN2; N2; NOTCH2

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UniProt ID: (Human) Q04721, (Mouse) O35516

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Entrez Gene ID: (Human) 4853, (Mouse) 18129

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Function(s)
receptor activity calcium ion binding protein binding transcription factor activity, ligand-activated RNA polymerase II transcription factor binding enzyme binding NF-kappaB binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development cell fate determination liver development placenta development heart looping morphogenesis of an epithelial sheet inflammatory response to antigenic stimulus pulmonary valve morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter humoral immune response cell cycle arrest Notch signaling pathway multicellular organism development determination of left/right symmetry positive regulation of cell proliferation negative regulation of cell proliferation organ morphogenesis cell growth cell differentiation embryonic limb morphogenesis positive regulation of BMP signaling pathway multicellular organism growth intrahepatic bile duct development wound healing defense response to bacterium myeloid dendritic cell differentiation positive regulation of apoptotic process positive regulation of osteoclast differentiation positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process atrial septum morphogenesis placenta blood vessel development ciliary body morphogenesis left/right axis specification hepatocyte proliferation liver morphogenesis interleukin-4 secretion cholangiocyte proliferation marginal zone B cell differentiation transcription initiation from RNA polymerase II promoter apoptotic process nervous system development stem cell population maintenance hemopoiesis intracellular receptor signaling pathway tissue regeneration negative regulation of apoptotic process Notch signaling involved in heart development
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