Abnova

NOG Polyclonal Antibody, MaxPab™

View all (32) Noggin antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
NOG Polyclonal Antibody, MaxPab™

Product Details

H00009241-B01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NOG (NP_005441.1, 1 a.a. approximately 232 a.a) full-length human protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC

Target Information

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Noggin; Noggin precursor; symphalangism 1 (proximal)

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Gene Aliases: NOG; SYM1; SYNS1; SYNS1A

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UniProt ID: (Human) Q13253

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Entrez Gene ID: (Human) 9241

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Function(s)
protein binding cytokine binding protein complex binding protein homodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation in utero embryonic development endoderm formation mesoderm formation epithelial to mesenchymal transition neural plate morphogenesis neural tube closure nervous system development motor neuron axon guidance dorsal/ventral pattern formation spinal cord development cell differentiation in hindbrain pituitary gland development negative regulation of cell migration BMP signaling pathway negative regulation of BMP signaling pathway somatic stem cell population maintenance wound healing middle ear morphogenesis embryonic digit morphogenesis regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter axial mesoderm development notochord morphogenesis embryonic skeletal system development negative regulation of astrocyte differentiation positive regulation of epithelial cell proliferation cartilage development negative regulation of cardiac muscle cell proliferation limb development embryonic skeletal joint morphogenesis negative regulation of cytokine activity face morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation lung morphogenesis prostatic bud formation ureteric bud formation fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of cartilage development somite development negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis positive regulation of glomerulus development regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of apoptotic signaling pathway
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