Proteintech

NODAL Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
NODAL Polyclonal Antibody

Product Details

27430-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:4,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800
-

Immunocytochemistry (ICC/IF)

1:200-1:800
-

Flow Cytometry (Flow)

0.40 µg/1x10^6 cell suspension
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: EWGKRHRRHH LPDRSQLCRK VKFQVDFNLI GWGSWIIYPK QYNAYRCEGE CPNPVGEEFH PTNHAYIQSL LKRYQPHRVP STCCAPVKTK PLSMLYVDNG RVLLDHHKDM IVEECGCL

Target Information

NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC138230; Nodal homolog

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Gene Aliases: HTX5; NODAL

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UniProt ID: (Human) Q96S42

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Entrez Gene ID: (Human) 4838

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Function(s)
cytokine activity transforming growth factor beta receptor binding growth factor activity morphogen activity receptor agonist activity type I activin receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter trophectodermal cellular morphogenesis neural fold formation liver development placenta development embryonic placenta development maternal placenta development vasculature development heart looping inhibition of neuroepithelial cell differentiation brain development embryonic pattern specification polarity specification of proximal/distal axis regulation of gastrulation positive regulation of vascular endothelial growth factor production negative regulation of cell development positive regulation of pathway-restricted SMAD protein phosphorylation stem cell population maintenance positive regulation of cell-cell adhesion BMP signaling pathway positive regulation of activin receptor signaling pathway floor plate morphogenesis endodermal cell differentiation cell migration involved in gastrulation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter axial mesodermal cell fate specification mesendoderm development digestive tract morphogenesis embryonic cranial skeleton morphogenesis formation of anatomical boundary positive regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity embryonic process involved in female pregnancy maternal process involved in parturition positive regulation of SMAD protein import into nucleus SMAD protein signal transduction left lung morphogenesis negative regulation of androgen receptor signaling pathway epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification positive regulation of ERK1 and ERK2 cascade transforming growth factor beta receptor signaling pathway involved in primitive streak formation nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of trophoblast cell migration negative regulation of chorionic trophoblast cell proliferation regulation of stem cell population maintenance
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