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NeoBiotechnologies

NME2/nm23-H2/NDPK-B (Suppressor of Metastasis) Monoclonal Antibody (NME2/6433)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Cite NME2/nm23-H2/NDPK-B (Suppressor of Metastasis) Monoclonal Antibody (NME2/6433)

NME2/nm23-H2/NDPK-B (Suppressor of Metastasis) Monoclonal Antibody (NME2/6433)

Product Details

4831-MSM3-P1

Applications
Tested Dilution
Publications

Western Blot (WB)

2-4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2, kappa

Class

Monoclonal

Type

Antibody

Clone

NME2/6433

Immunogen

Recombinant full-length human NME2 protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control: A549 HeLa or Jurkat cells. Ubiquitously expressed in all tissues. PC3

Cellular Location: Cytoplasm. Nucleus.

Target Information

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.13.3; C-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; HEL-S-155an; Histidine protein kinase NDKB; NDK B; NDP kinase B; nm23-H2; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; Nucleoside diphosphate kinase B; nucleotide diphosphate kinase B

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Gene Aliases: NDKB; NDPK-B; NDPKB; NM23-H2; NM23B; NME2; PUF

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UniProt ID: (Human) P22392

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Entrez Gene ID: (Human) 4831

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding nucleoside diphosphate kinase activity protein histidine kinase activity protein binding ATP binding metal ion binding
Process(es)
purine nucleotide metabolic process nucleoside diphosphate phosphorylation GTP biosynthetic process pyrimidine nucleotide metabolic process UTP biosynthetic process CTP biosynthetic process transcription, DNA-templated regulation of transcription, DNA-templated cell adhesion integrin-mediated signaling pathway nucleoside triphosphate biosynthetic process nucleobase-containing small molecule interconversion peptidyl-histidine phosphorylation negative regulation of apoptotic process positive regulation of keratinocyte differentiation regulation of epidermis development positive regulation of transcription from RNA polymerase II promoter positive regulation of epithelial cell proliferation mitophagy in response to mitochondrial depolarization
It has to be done as per old AB suggested Products section.
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