Invitrogen

NME2 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
NME2 Polyclonal Antibody

Product Details

PA5-96679

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human NME2/NM23B (NP_0010181481)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808481

Product Specific Information

Immunogen sequence: MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVKSAEKEI SLWFKPEELV DYKSCAHDWV YE; Positive Samples: PC-12, 22Rv1, Mouse kidney, Mouse liver, Rat liver; Cellular Location: Cell projection, Cytoplasm, Nucleus, lamellipodium, ruffle

Target Information

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.13.3; C-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; expressed in non-metastatic cells 2; expressed in non-metastatic cells 2 protein; HEL-S-155an; Histidine protein kinase NDKB; NDK B; NDP kinase alpha; NDP kinase B; nm23-H2; nm23-M2; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; Nucleoside diphosphate kinase B; nucleoside-diphosphate kinase 2; nucleotide diphosphate kinase B; P18

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Gene Aliases: NDKB; NDPK-B; NDPKB; nm23-2; NM23-H2; nm23-M2; NM23B; NME2; p18-12d; PUF

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UniProt ID: (Human) P22392, (Rat) P19804, (Mouse) Q01768

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Entrez Gene ID: (Human) 4831, (Rat) 83782, (Mouse) 18103

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding nucleoside diphosphate kinase activity protein histidine kinase activity protein binding ATP binding metal ion binding protein serine/threonine kinase activity fatty acid binding drug binding intermediate filament binding enzyme binding nucleotide binding kinase activity transferase activity
Process(es)
negative regulation of myeloid leukocyte differentiation nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process integrin-mediated signaling pathway nucleoside triphosphate biosynthetic process positive regulation of neuron projection development peptidyl-histidine phosphorylation positive regulation of cAMP biosynthetic process cellular response to oxidative stress regulation of apoptotic process negative regulation of apoptotic process positive regulation of keratinocyte differentiation regulation of epidermis development positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation positive regulation of epithelial cell proliferation protein oligomerization response to growth hormone cellular response to glucose stimulus cellular response to fatty acid purine nucleotide metabolic process pyrimidine nucleotide metabolic process nucleotide metabolic process phosphorylation mitophagy in response to mitochondrial depolarization transcription, DNA-templated regulation of transcription, DNA-templated cell adhesion nucleobase-containing small molecule interconversion
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