Invitrogen

NME1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
NME1 Polyclonal Antibody

Product Details

PA5-86591

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 20-70 of Human NM23-H1.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2803361

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in the gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: expressed in non-metastatic cells 1 protein; expressed in non-metastatic cells 1 protein (NM23A) (nucleoside diphosphate kinase); expressed in non-metastatic cells 1, protein; expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase); GAAD; Granzyme A activated DNase (GAAD); Granzyme A-activated DNase; GZMA activated DNase; included; Metastasis inhibition factor NM23; NDK A; NDP kinase A; NDP kinase beta; NDPK-A; NM23-H1; nm23-M1; NM23H1B; NME1-NME2 spliced read-through transcript; non-metastatic cells 1, protein (NM23A) expressed in; Nucleoside diphosphate kinase A; nucleoside-diphosphate kinase 1; nucleotide diphosphate kinase; nucloside diphosphate kinase; Tumor metastatic process-associated protein

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Gene Aliases: AL024257; AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1; NM23-M1; NM23A; NME1

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UniProt ID: (Human) P15531, (Mouse) P15532, (Rat) Q05982

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Entrez Gene ID: (Human) 4830, (Mouse) 18102, (Rat) 191575

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Function(s)
magnesium ion binding RNA polymerase II regulatory region sequence-specific DNA binding single-stranded DNA binding deoxyribonuclease activity nucleoside diphosphate kinase activity protein binding ATP binding GTP binding intermediate filament binding protein kinase binding identical protein binding gamma-tubulin binding ribosomal small subunit binding poly(A) RNA binding nucleotide binding kinase activity transferase activity enzyme binding metal ion binding
Process(es)
negative regulation of myeloid leukocyte differentiation purine nucleotide metabolic process nucleoside diphosphate phosphorylation GTP biosynthetic process pyrimidine nucleotide metabolic process UTP biosynthetic process CTP biosynthetic process DNA metabolic process endocytosis lactation negative regulation of cell proliferation nucleoside triphosphate biosynthetic process negative regulation of gene expression positive regulation of neuron projection development response to amine nucleobase-containing small molecule interconversion hippocampus development response to testosterone cellular response to drug regulation of apoptotic process positive regulation of DNA binding positive regulation of epithelial cell proliferation response to cAMP cellular response to glucose stimulus cellular response to fatty acid nervous system development nucleotide metabolic process phosphorylation cell differentiation mammary gland development nucleic acid phosphodiester bond hydrolysis DNA catabolic process integrin-mediated signaling pathway response to drug negative regulation of apoptotic process positive regulation of keratinocyte differentiation positive regulation of transcription from RNA polymerase II promoter
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