Invitrogen

NLRP3 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
NLRP3 Polyclonal Antibody

Product Details

PA5-115661

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NLRP3(Accession Q96P20), corresponding to amino acid residues L1005-W1036.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900296

Product Specific Information

Antibody detects endogenous levels of total NLRP3.

Target Information

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein; Cold autoinflammatory syndrome 1 protein homolog; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; FLJ95925; mast cell maturation inducible protein 1; Mast cell maturation-associated-inducible protein 1; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NLR family, pyrin domain containing 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYRIN-containing APAF1-like protein 1

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Gene Aliases: AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; Mmig1; MWS; NALP3; NLRP3; PYPAF1

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UniProt ID: (Human) Q96P20, (Rat) D4A523, (Mouse) Q8R4B8

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Entrez Gene ID: (Human) 114548, (Rat) 287362, (Mouse) 216799

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Function(s)
protein binding ATP binding transcription factor binding peptidoglycan binding sequence-specific DNA binding molecular_function nucleotide binding
Process(es)
negative regulation of acute inflammatory response positive regulation of type 2 immune response transcription, DNA-templated apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response inflammatory response signal transduction detection of biotic stimulus negative regulation of NF-kappaB transcription factor activity interleukin-1 beta production interleukin-18 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production negative regulation of NF-kappaB import into nucleus positive regulation of cysteine-type endopeptidase activity involved in apoptotic process NLRP3 inflammasome complex assembly innate immune response positive regulation of T-helper 2 cell differentiation positive regulation of transcription from RNA polymerase II promoter interleukin-1 secretion negative regulation of interleukin-1 beta secretion positive regulation of interleukin-1 beta secretion negative regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity protein oligomerization defense response to virus cellular response to lipopolysaccharide positive regulation of T-helper 17 cell differentiation positive regulation of T-helper 2 cell cytokine production biological_process regulation of inflammatory response
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