Invitrogen

NLGN3 Monoclonal Antibody (N110/29), FITC

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Datasheet
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Datasheet
Protocols
Questions & Answers
NLGN3 Monoclonal Antibody (N110/29), FITC

Product Details

MA5-45698

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N110/29

Immunogen

Fusion protein amino acids 730-848 (intracellular C-terminus) of rat Neuroligin-3.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.4, with 581mM DMSO, 123mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932152

Product Specific Information

Mouse: 99% identity (118/119 amino acids identical). Human: 98% identity (116/119 amino acids identical) ~60% identity with Neuroligin-1. ~40% identity with Neuroligin-2.

1 µg/mL of MA5-45698 was sufficient for detection of Neuroligin 3 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 110kDa. Does not cross-react with Neuroligin-1, -2, -4 or -4.

This antibody was formerly sold as clone S110-29.

Target Information

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASPGX1; AUTSX1; Gliotactin homolog; neuroligin 3 protein; Neuroligin-3

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Gene Aliases: A230085M13Rik; HNL3; KIAA1480; NL3; NLGN3

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UniProt ID: (Human) Q9NZ94, (Mouse) Q8BYM5, (Rat) Q62889

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Entrez Gene ID: (Human) 54413, (Mouse) 245537, (Rat) 171297

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Function(s)
receptor activity protein binding neurexin family protein binding cell adhesion molecule binding carboxylic ester hydrolase activity scaffold protein binding
Process(es)
regulation of respiratory gaseous exchange by neurological system process receptor-mediated endocytosis neuron cell-cell adhesion synapse assembly learning visual learning adult behavior social behavior axon extension oligodendrocyte differentiation modulation of synaptic transmission synapse organization positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic rhythmic synaptic transmission excitatory postsynaptic potential inhibitory postsynaptic potential long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine morphogenesis vocalization behavior negative regulation of excitatory postsynaptic potential postsynaptic membrane assembly presynaptic membrane assembly positive regulation of inhibitory postsynaptic potential regulation of long-term synaptic potentiation positive regulation of protein localization to synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of terminal button organization positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity cell adhesion regulation of synaptic transmission, glutamatergic regulation of dendritic spine morphogenesis regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity metabolic process
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