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Proteintech
NISCH Polyclonal Antibody
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Product Details
13813-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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Product Specific Information
Immunogen sequence: NEELRHLMW SSVVFYQTPG LEVTACVLLS TKAVYFVLHD GLRRYFSEPL QDFWHQKNTD YNNSPFHISQ CFVLKLSDLQ SVNVGLFDQH FRLTGSTPMQ VVTCLTRDSY LTHCFLQHLM VVLSSLERTP SPEPVDKDFY SEFGNKTTGK MENYELIHSS RVKFTYPSEE EIGDLTFTVA QKMAEPEKAP ALSILLYVQA FQVGMPPPGC CRGPLRPKTL LLTSSEIFLL DEDCVHYPLP EFAKEPPQRD RYRLDDGRRV RDLDRVLMGY QTYPQALTLV FDDVQGHDLM GSVTLDHFGE VPGGPARASQ GREVQWQVFV PSAESREKLI SLLARQWEAL CGRELPVELT G (1155-1504 aa encoded by BC038102)
Target Information
Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hIRAS; I-1; I-1 receptor candidate protein; I1R; I1R candidate protein; Imidazoline receptor 1; imidazoline receptor antisera selected; Imidazoline receptor antisera-selected protein; imidazoline receptor I-1; Imidazoline receptor I-1-like protein; Imidazoline-1 receptor; Imidazoline-1 receptor candidate protein; IR1; Nischarin
Gene Aliases: 1200007D05Rik; 3202002H23Rik; AW494485; hIRAS; I-1; IR1; IRAS; KIAA0975; NISCH
UniProt ID: (Human) Q9Y2I1, (Mouse) Q80TM9
Entrez Gene ID: (Human) 11188, (Rat) 306255, (Mouse) 64652
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