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Proteintech
NELF-A Polyclonal Antibody
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Product Details
10456-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: ESDTGLWLH NKLGATDELW APPSIASLLT AAVIDNIRLC FHGLSSAVKL KLLLGTLHLP RRTVDEMKGA LMEIIQLASL DSDPWVLMVA DILKSFPDTG SLNLELEEQN PNVQDILGEL REKVGECEAS AMLPLECQYL NKNALTTLAG PLTPPVKHFQ LKRKPKSATL RAELLQKSTE TAQQLKRSAG VPFHAKGRGL LRKMDTTTPL KGIPKQAPFR SPTAPSVFSP TGNRTPIPPS RTLLRKERGV KLLDISELDM VGAGREAKRR RKTLDAEVVE KPAKEETVVE NATPDYAAGL VSTQKLGSLN (6-314 aa encoded by BC002764)
Target Information
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ10442; FLJ25112; mWHSC2; Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 homolog; Wolf-Hirschhorn syndrome candidate 2 protein
Gene Aliases: NELF-A; NELFA; P/OKcl.15; WHSC2; Whsc2h
UniProt ID: (Human) Q9H3P2, (Mouse) Q8BG30
Entrez Gene ID: (Human) 7469, (Mouse) 24116
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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