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Invitrogen
NAGA Polyclonal Antibody
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Product Details
PA5-51433
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Immunogen sequence: WLAWERFRCN INCDEDPKNC ISEQLFMEMA DRMAQDGWRD MGYTYLNIDD CWIGGRDASG RLMPDPKRFP HGIPFLADYV HSLGLKLGIY ADMGNFTCMG YPGTTLDKVV QDAQTFAEWK VDMLKLDGCF ST
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
NAGA (N-acetylgalactosaminidase, alpha), also known as alpha-galactosidase B or GALB, is a 411 lysosomal protein belonging to the glycosyl hydrolase 27 family that may exist as a homodimer and plays a critical role in glycolipid breakdown. NAGA encodes alpha-N-acetylgalactosaminidase, a lysosomal enzyme, which cleaves alpha-N-acetylgalactosaminyl groups from glycoconjugates. Mapping to human chromosome 22q13. 2, NAGA defects are the cause of an autosomal recessive disorder with three phenotypes, known as Schindler disease (types I, II and III) or NAGA deficiency (types I, II and III). Characterized by neurologic manifestations that range in severity, Schindler disease type I is the most severe form, followed by type III, which may have mild-to-moderate effects. Schindler disease type II, also known as Kanzaki disease, is characterized by mild intellectual impairment and angiokeratoma corporis diffusum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Acetylgalactosaminidase, alpha-N- (alpha-galactosidase B); Alpha-galactosidase B; Alpha-N-acetylgalactosaminidase; EC 3.2.1; EC 3.2.1.49; galactosidase-alphaB; galactosidasealphaB; N-acetylgalactosaminidase, alpha-
Gene Aliases: D22S674; GALB; NAGA
UniProt ID: (Human) P17050
Entrez Gene ID: (Human) 4668
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