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Abnova
NAB2 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
NAB2 Antibody (H00004665-B01P) in WB
Lane 1: NAB2 transfected lysate(26.51 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00004665-B01P
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Sequence of this protein is as follows: MHRAPSPTAE QPPGGGDSAR RTLQPRLKPS ARAMALPRTL GELQLYRVLQ RANLLSYYET FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG DPRIWPGRST PESDVGAGGE EEAGSRWDWG WSRPTGARDG TPACLGRVWM DICRLWGHVQ G
Target Information
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: EGR-1-binding protein 2; EGR1 binding protein 2; Melanoma-associated delayed early response protein; NGFI-A binding protein 2 (EGR1 binding protein 2); NGFI-A-binding protein 2; Protein MADER
Gene Aliases: MADER; NAB2
UniProt ID: (Human) Q15742
Entrez Gene ID: (Human) 4665
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