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Proteintech
NAB2 Polyclonal Antibody
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Product Details
19601-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MHRAPSPTA EQPPGGGDSA RRTLQPRLKP SARAMALPRT LGELQLYRVL QRANLLSYYE TFIQQGGDDV QQLCEAGEEE FLEIMALVGM ATKPLHVRRL QKALREWATN PGLFSQPVPA VPVSSIPLFK ISETAGTRKG SMSNGHGSPG EKAGSARSFS PKSPLELGEK LSPLPGGPGA GDPRIWPGRS TPESDVGAGG EEEAGSPPFS PPAGGGVPEG TGAGGLAAGG TGGGPDRLEP EMVRMVVESV ERIFRSFPRG DAGEVTSLLK LNKKLARSVG HIFEMDDNDS QKEEEIRKYS IIYGRFDSKR REGKQLSLHE L (1-320 aa encoded by BC065931)
Target Information
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EGR-1-binding protein 2; EGR1 binding protein 2; Melanoma-associated delayed early response protein; NGFI-A binding protein 2 (EGR-1 binding protein 2); NGFI-A binding protein 2 (EGR1 binding protein 2); NGFI-A-binding protein 2; Protein MADER
Gene Aliases: AI451907; MADER; NAB2
UniProt ID: (Human) Q15742, (Mouse) Q61127
Entrez Gene ID: (Human) 4665, (Mouse) 17937, (Rat) 314910
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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