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Invitrogen
MICALCL Polyclonal Antibody
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Product Details
PA5-59178
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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RRID
Product Specific Information
Immunogen sequence: IRRSLEPLLS NSEGGKKAWA KQESKTLPTQ ACTRSFSLRK TNSNKDGDQH SPGRNQSSAF SPPDPALRTH SLPNRPSKVF PALRSPPCSK IEDVPTLL
Highest antigen sequence identity to the following orthologs: Mouse - 49%, Rat - 50%.
Target Information
MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL2 has three conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain and a Lin11, Isl-1 and Mec-3 (LIM) domain. It has been demonstrated that MICAL2 could regulate actin stress fibers and is required for normal actin organization. In addition, MICAL2-PV, a novel splicing variants of MICAL2, has been reported to be involved in cancer progression of prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: [F-actin]-monooxygenase MICAL2; flavoprotein oxidoreductase MICAL2; MICAL C-terminal-like protein; MICAL-2; Mical-cL; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2
Gene Aliases: KIAA0750; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; MICALCL
UniProt ID: (Human) O94851
Entrez Gene ID: (Human) 9645
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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