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Abnova
MIB1 Monoclonal Antibody (3E10)
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Product Details
H00057534-M02
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
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Purification
Storage buffer
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Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: PFIMCCGGKS SEDATDDISS GNIPVLQKDK DNTNVNADVQ KLQQQLQDIK EQTMCPVCLD RLKNMIFLCG HGTCQLCGDR MSECPICRKA IERRILLY
Target Information
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DAPK-interacting protein 1; DIP-1; E3 ubiquitin-protein ligase MIB1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1; ubiquitin ligase mind bomb; Zinc finger ZZ type with ankyrin repeat domain protein 2
Gene Aliases: DIP-1; DIP1; KIAA1323; LVNC7; MIB; MIB1; ZZANK2; ZZZ6
UniProt ID: (Human) Q86YT6
Entrez Gene ID: (Human) 57534
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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