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Invitrogen
MIB1 Polyclonal Antibody
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FIGURE: 1 / 1
MIB1 Antibody (PA5-97126) in WB
Product Details
PA5-97126
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Immunogen sequence: DSEGDTPLHD AISKKRDDIL AVLLEAGADV TITNNNGFNA LHHAALRGNP SAMRVLLSKL PRPWIVDEKK DDGYTALHLA ALNNHVEVAE LLVHQGNANL DIQNVNQQTA LHLAVERQHT QIVRLLVRAG AKLDIQDKDG DTPLHEALRH HTLSQLRQLQ DMQDVGKVDA AWEPSKNTLI MGLGTQGAEK KSAASIACFL AANGADLSIR NKKGQSPLDL CPDPNLCKAL AKCHKEKVSG QVGSRSPSMI SNDSETLEEC MVCSDMKRDT LFGPCGHIAT CSLCSPRVKK CLICKEQVQS R; Positive Samples: U-87MG, A-549, HepG2, Mouse stomach, Mouse lung, Mouse kidney, Rat testis; Cellular Location: Cell membrane, Cytoplasm, centriolar satellite, centrosome, cytoskeleton, microtubule organizing center
Target Information
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DAPK-interacting protein 1; DAPK-interacting protein-1; DIP-1; E3 ubiquitin-protein ligase MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb homolog 1; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; Zinc finger ZZ type with ankyrin repeat domain protein 2
Gene Aliases: DIP-1; DIP1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; mKIAA1323; ZZANK2; ZZZ6
UniProt ID: (Human) Q86YT6, (Mouse) Q80SY4
Entrez Gene ID: (Human) 57534, (Mouse) 225164, (Rat) 307594
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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