Invitrogen

LIS1 Polyclonal Antibody

View all (12) LIS1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
LIS1 Polyclonal Antibody

Product Details

PA5-18048

Applications
Tested Dilution
Publications

Western Blot (WB)

0.3-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

3.75 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (TGSVDQTVKVWECR) corresponding to the C-terminus amino acids of PAFAH1B1 (aa 397-410).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10981204

Product Specific Information

This antibody is predicted to react with bovine, canine, mouse and porcine based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: LIS-1; LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141}; lissencephaly 1 protein; Lissencephaly-1 protein; lissencephaly-1 protein {ECO:0000255|HAMAP-Rule:MF_03141}; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF acetylhydrolase 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH 45 kDa subunit; PAF-AH 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH alpha; PAF-AH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH beta; PAFAH alpha; PAFAH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PAFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta); Platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase IB subunit alpha {ECO:0000255|HAMAP-Rule:MF_03141}; Platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD); platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa; platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa); RP23-194P5.2

View more View less

Gene Aliases: Lis-1; LIS1; LIS2; MDCR; MDS; NudF; PAFAH; PAFAH1B1; PAFAHA

View more View less

UniProt ID: (Human) P43034, (Rat) P63004

View more View less

Entrez Gene ID: (Human) 5048, (Rat) 83572

View more View less

Function(s)
phospholipase A2 activity protein binding microtubule binding heparin binding protein complex binding dynactin binding protein homodimerization activity phospholipase binding dynein binding dynein intermediate chain binding phosphoprotein binding platelet-activating factor acetyltransferase activity
Process(es)
establishment of mitotic spindle orientation microtubule cytoskeleton organization ameboidal-type cell migration acrosome assembly neuron migration positive regulation of cytokine-mediated signaling pathway microtubule-based process mitotic nuclear division nuclear migration chemical synaptic transmission neuroblast proliferation brain development learning or memory retrograde axonal transport adult locomotory behavior protein secretion negative regulation of neuron projection development lipid catabolic process cell migration stem cell division transmission of nerve impulse corpus callosum morphogenesis hippocampus development layer formation in cerebral cortex cerebral cortex neuron differentiation cerebral cortex development actin cytoskeleton organization microtubule organizing center organization osteoclast development positive regulation of axon extension positive regulation of mitotic cell cycle negative regulation of JNK cascade vesicle transport along microtubule brain morphogenesis neuromuscular process controlling balance nuclear envelope disassembly establishment of centrosome localization G2/M transition of mitotic cell cycle sister chromatid cohesion germ cell development positive regulation of embryonic development establishment of planar polarity of embryonic epithelium regulation of GTPase activity cortical microtubule organization platelet activating factor metabolic process auditory receptor cell development positive regulation of dendritic spine morphogenesis regulation of microtubule cytoskeleton organization cochlea development microtubule cytoskeleton organization involved in establishment of planar polarity regulation of microtubule motor activity
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support