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Invitrogen
LDLR Polyclonal Antibody
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Product Details
PA5-20752
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
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Shipping conditions
RRID
Product Specific Information
A suggested positive control is human liver tissue lysate.
PA5-20752 can be used with blocking peptide PEP-0866.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Gene Aliases: FH; FHC; Hlb301; LDLCQ2; LDLR; LDLRA
UniProt ID: (Human) P01130, (Mouse) P35951, (Rat) P35952
Entrez Gene ID: (Human) 3949, (Mouse) 16835, (Rat) 300438
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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