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Abnova
KITLG Monoclonal Antibody (2C7)
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Product Details
H00004254-M08
Species Reactivity
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Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: EGICRNRVTN NVKDVTKLVA NLPKDYMITL KYVPGMDVLP SHCWISEMVV QLSDSLTDLL DKFSNISEGL SNYSIIDKLV NIVDDLVECV KENSSKDLKK SFKSPEPRLF TPEEFFRIFN RSIDAFKDFV VASETSDCVV SSTLSPEKGK AKNPPGDSSL HWAAMALPAL FSLIIGFAFG ALYWKKRQPS LTRAVENIQI NEEDNEISML QEKEREFQEV
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: C-kit ligand; cloud gray; DKFZp686F2250; familial progressive hyperpigmentation 2; grizzle-belly; H-SCF; Hematopoietic growth factor KL; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; SCF; Steel factor; Stem cell factor
Gene Aliases: blz; Clo; Con; contrasted; DCUA; DFNA69; FPH2; FPHH; Gb; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7; Sl; SLF
UniProt ID: (Human) P21583, (Mouse) P20826
Entrez Gene ID: (Human) 4254, (Mouse) 17311
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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