QED Bioscience

KDEL Receptor Monoclonal Antibody (KR-10)

View all (19) KDEL antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
KDEL Receptor Monoclonal Antibody (KR-10)

Product Details

11078-100UG

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunocytochemistry (ICC/IF)

1:1,000
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Fruit fly, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat, Xenopus

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

KR-10

Immunogen

Peptide corresponding to aa 192-212 of bovine KDEL receptor
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 78 kDa glucose-regulated protein; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250|UniProtKB:P08113}; 98 kDa protein kinase; Binding-immunoglobulin protein; BiP; BiP protein; CG5183-PA; CG5183-PB; CG5183-PC; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250|UniProtKB:P08113}; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; ER lumen protein retaining receptor 1; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor; ER lumen protein-retaining receptor 1; ERp99; glucose regulated protein, 78 kDa; glucose-regulated protein; glucose-regulated protein GRP94; glucose-regulated protein, 78kDa; gp96 homolog; GRP 78; GRP-78; GRP-94; GRP94; Heat shock 108 kDa protein; heat shock 70 kDa protein 5; heat shock 70 kDa protein 5a; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 108; heat shock protein 5; Heat shock protein 70 family protein 5; Heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250|UniProtKB:P08113}; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta, member 1; Heat shock protein family A member 5; Heat shock protein family C member 4; heavy-chain binding protein BiP; HSP 108; HSP70 family protein 5; HSP90 beta; hsp90b1 {ECO:0000250|UniProtKB:P08113}; immunoglobulin binding protein; Immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor; KDEL receptor 1; KDEL-receptor; KdelR-PA; KdelR-PB; KdelR-PC; lethal (2) 31Em; Lys-Asp-Glu-Leu; Polymorphic tumor rejection antigen 1; PPK 98; Putative MAPK-activating protein PM23; RP23-446N16.1; Steroidogenesis-activator polypeptide; stress-inducible tumor rejection antigen gp96; Transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen gp96; XAP-1 antigen

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Gene Aliases: 8030486F04Rik; AL022860; AU019543; AW215843; baffled; BEST:CK00230; BIP; BiP/Grp78; BOS_12003; BOS_17737; BOS_5572; CG5183; CK00230; D2Wsu141e; D2Wsu17e; Dmel\CG5183; Dmel_CG5183; dmErd2; ECGP; endoplasmin; ERD2; ERD2.1; ERp99; GP96; GRP78; GRP94; HDEL; HEL-S-125m; HEL-S-89n; HEL35; Hsce70; hsp108; HSP90B1; HSPA5; hspa5a; HSPC4; I79_019946; I79_020931; KDELR; KDELR1; l(2)31Em; l(2)k00311; mBiP; MIF2; PM23; ppk98; SEZ-7; Sez7; TA-3; Targ2; Tra-1; TRA1; XAP-1; XELAEV_180384511mg

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UniProt ID: (Pig) Q29092, (Dog) P41148, (Bovine) Q95M18, (Chicken) P08110, (Human) P14625, (Chicken) Q90593, (Bovine) Q0VCX2, (Human) P11021, (Rat) Q66HD0, (Mouse) P08113, (Mouse) P20029, (Chinese hamster) G3I8R9, (Rat) P06761, (Bovine) P33946, (Human) P24390, (Fruit fly) O76767, (Mouse) Q99JH8, (Rat) Q569A6, (Rabbit) O18750, (Xenopus) Q91883

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Entrez Gene ID: (Pig) 397191, (Dog) 404019, (Bovine) 282646, (Chicken) 374163, (Human) 7184, (Sheep) 101111703, (Chicken) 396487, (Sheep) 780447, (Dog) 480726, (Pig) 407060, (Bovine) 415113, (Human) 3309, (Chinese hamster) 100773331, (Rat) 362862, (Mouse) 22027, (Mouse) 14828, (Chinese hamster) 100689305, (Rat) 25617, (Bovine) 618184, (Sheep) 101122047, (Human) 10945, (Dog) 484406, (Fruit fly) 34427, (Chinese hamster) 100750912, (Mouse) 68137, (Rat) 361577, (Rabbit) 100008764, (Rabbit) 100009456, (Rabbit) 100349892, (Xenopus) 397850

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Function(s)
ATP binding unfolded protein binding RNA binding protein phosphatase binding virion binding low-density lipoprotein particle receptor binding calcium ion binding protein binding protein domain specific binding ubiquitin protein ligase binding ribosome binding misfolded protein binding glycoprotein binding ATPase activity enzyme binding chaperone binding cadherin binding involved in cell-cell adhesion nucleotide binding ER retention sequence binding KDEL sequence binding molecular_function
Process(es)
ER overload response activation of signaling protein activity involved in unfolded protein response cerebellum structural organization cerebellar Purkinje cell layer development negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein ubiquitination cellular response to glucose starvation negative regulation of apoptotic process proteolysis involved in cellular protein catabolic process cellular response to interleukin-4 protein retention in ER lumen protein transport vesicle-mediated transport response to hypoxia protein folding ER-associated ubiquitin-dependent protein catabolic process actin rod assembly regulation of phosphoprotein phosphatase activity cellular response to ATP positive regulation of cell migration response to endoplasmic reticulum stress maintenance of protein localization in endoplasmic reticulum positive regulation of embryonic development toxin transport response to stress intracellular protein transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER sensory perception of pain substantia nigra development cellular response to antibiotic toll-like receptor signaling pathway receptor-mediated endocytosis retrograde protein transport, ER to cytosol protein folding in endoplasmic reticulum ATF6-mediated unfolded protein response sequestering of calcium ion transport biological_process endoplasmic reticulum unfolded protein response IRE1-mediated unfolded protein response PERK-mediated unfolded protein response regulation of protein folding in endoplasmic reticulum cellular response to manganese ion negative regulation of protein homodimerization activity cell-cell adhesion regulation of ATF6-mediated unfolded protein response regulation of IRE1-mediated unfolded protein response regulation of PERK-mediated unfolded protein response positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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