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NeoBiotechnologies
IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Monoclonal Antibody (IA761), CF® 488
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Product Details
3493-MSM2-CF488-100T
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Excitation/Emission Max
Form
Concentration
Purification
Storage buffer
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Shipping conditions
Target Information
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Immunoglobulin Heavy Constant Alpha 1; Immunoglobulin Heavy Constant Alpha 2
Gene Aliases: IgA1
Entrez Gene ID: (Human) 3493
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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