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Invitrogen
ITM2B Polyclonal Antibody
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Product Details
PA5-67219
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Immunogen sequence: MVKVTFNSALA QKEAKKDEPK SGEEALIIPP DAVAVDCKDP DDVVPVGQRR A
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 96%.
Target Information
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: ABri/ADan amyloid peptide; Bri; BRICHOS domain containing 2B; imBRI2; Immature BRI2; Integral membrane protein 2B; OTTHUMP00000018394; Protein E25B; RP11-196P14.1; Transmembrane protein BRI
Gene Aliases: ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2; ITM2B; RDGCA
UniProt ID: (Human) Q9Y287
Entrez Gene ID: (Human) 9445
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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