Abnova

IGF2 Polyclonal Antibody, MaxPab™

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Datasheet
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Questions & Answers
Datasheet
Protocols
Questions & Answers
IGF2 Polyclonal Antibody, MaxPab™

Product Details

H00003481-B02P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IGF2 (NP_000603.1, 1 a.a. approximately 180 a.a) full-length human protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK

Target Information

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ22066; FLJ44734; H-IGF-2; IGF; IGF-II; Insulin like growth factor; Insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; insulin-like growth factor type 2; preptin; Somatomedin-A; T3M-11-derived growth factor

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Gene Aliases: C11orf43; GRDF; IGF-2; IGF-II; IGF2; PP1446; PP9974

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UniProt ID: (Human) P01344

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Entrez Gene ID: (Human) 3481

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Function(s)
insulin receptor binding insulin-like growth factor receptor binding hormone activity protein binding growth factor activity receptor activator activity protein serine/threonine kinase activator activity
Process(es)
skeletal system development ossification positive regulation of protein phosphorylation platelet degranulation glucose metabolic process regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated multicellular organism development female pregnancy memory positive regulation of cell proliferation insulin receptor signaling pathway response to radiation response to nutrient levels response to estradiol response to nicotine insulin receptor signaling pathway via phosphatidylinositol 3-kinase wound healing positive regulation of activated T cell proliferation response to drug positive regulation of catalytic activity positive regulation of MAPK cascade cellular protein metabolic process response to ethanol positive regulation of glycogen biosynthetic process positive regulation of mitotic nuclear division negative regulation of natural killer cell mediated cytotoxicity positive regulation of insulin receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation positive regulation of cell division positive regulation of protein kinase B signaling cellular response to mechanical stimulus positive regulation of protein serine/threonine kinase activity positive regulation of receptor activity positive regulation of glycogen (starch) synthase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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