Proteintech

Huntingtin Polyclonal Antibody

View all (46) Huntingtin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Huntingtin Polyclonal Antibody

Product Details

27206-1-AP

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Huntingtin Fusion Protein Ag25922 (2845-3000 aa encoded by NM_002111)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LDVGPEFSA SIIQMCGVML SGSEESTPSI IYHCALRGLE RLLLSEQLSR LDAESLVKLS VDRVNVHSPH RAMAALGLML TCMYTGKEKV SPGRTSDPNP AAPDSESVIV AMERVSVLFD RIRKGFPCEA RVVARILPQF LDDFFPPQDI MNKVIGE (2845-3000 aa encoded by NM_002111)

Target Information

Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HD protein; HD protein homolog; Huntingtin; Huntington disease gene homolog; Huntington disease protein; huntington disease protein homolog

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Gene Aliases: AI256365; C430023I11Rik; HD; Hdh; HTT; IT15

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UniProt ID: (Human) P42858

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Entrez Gene ID: (Human) 3064, (Mouse) 15194

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Function(s)
p53 binding receptor binding protein binding profilin binding transcription factor binding dynactin binding identical protein binding ion channel binding dynein intermediate chain binding beta-tubulin binding diazepam binding
Process(es)
establishment of mitotic spindle orientation retrograde vesicle-mediated transport, Golgi to ER apoptotic process Golgi organization central nervous system development positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity regulation of protein phosphatase type 2A activity vocal learning positive regulation of cilium assembly vesicle transport along microtubule animal organ development mRNA transport negative regulation of cysteine-type endopeptidase activity negative regulation of extrinsic apoptotic signaling pathway urea cycle citrulline metabolic process protein import into nucleus mitochondrial transport ER to Golgi vesicle-mediated transport mitochondrion organization endoplasmic reticulum organization dopamine receptor signaling pathway spermatogenesis gastrulation brain development cell aging learning or memory learning grooming behavior locomotory behavior axo-dendritic transport associative learning determination of adult lifespan visual learning anatomical structure morphogenesis embryo development anterior/posterior pattern specification endosomal transport lactate biosynthetic process from pyruvate quinolinate biosynthetic process striatum development olfactory lobe development neural plate formation neurogenesis peptide hormone secretion insulin secretion social behavior hormone metabolic process negative regulation of apoptotic process negative regulation of neuron apoptotic process regulation of mitochondrial membrane permeability regulation of synaptic plasticity paraxial mesoderm formation neuron development neuron apoptotic process response to calcium ion regulation of mitochondrial membrane potential L-glutamate import iron ion homeostasis negative regulation of neuron death
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